Purine derivatives as drugs for the treatment of neonatal hypoxia-ischemia brain injury and related diseases

A compound of formula (I)

• or an addition salt thereof with a pharmaceutically acceptable acid,
• where:
• M represents a NR1R2 group, an OR1 group or a SR1 group,
• A represents a NR4R5 group,
• R1 is an aryl group, a heteroaryl group, a —CH2-aryl group or a —CH2-heteroaryl group, said aryl and heteroaryl being optionally substituted with one or more substituents independently chosen from a halogen atom, a CF3 group, a hydroxyl group, an OR6 group, a SR6 group, a NR6R7 group, a CN group, a CONR6R7 group, a SOR6 group, a SO2R6 group, an azido group (—N3), an aryl group, a heteroaryl group and a (C1-C6)alkyl group,
• R2 is a (C1-C6)alkyl group or a (C1-C6)cycloalkyl group said alkyl and cycloalkyl group being optionally substituted with one or more substituents independently chosen from a halogen atom, a hydroxyl group and a NH2 group,
• or R1 forms together with R2 and with the nitrogen atom that bears R1 and R2 an heterobicyclic ring,
• R6 and R7 represent independently of each other a hydrogen atom or a (C1-C6)alkyl group,
• R3 is a (C1-C6)alkyl group, a (C1-C6)cycloalkyl group, an aryl group, a —CH2-aryl group, a CH2—(C1-C6)cycloalkyl group or a —CH2-heteroaryl group, said alkyl, cycloalkyl, aryl and heteroaryl group being optionally substituted with one or more substituents independently chosen from a halogen atom, a hydroxyl group and a NH2 group,
• R4 is a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6)cycloalkyl group, an aryl group or a heteroaryl group, said alkyl and cycloalkyl group being optionally substituted with one or more substituents independently chosen from a halogen atom, a hydroxyl group and a NH2 group, said aryl and heteroaryl being optionally substituted with one or more substituents chosen from a halogen atom, a hydroxyl group, a NH2 group and a NH—R9 group,
• R9 is a heteroaryl group optionally substituted with one or more substituents chosen from a halogen atom, a hydroxyl group, a NH2 group and a heteroaryl group,
• R5 is a (C1-C8)alkyl group or a (C1-C6)cycloalkyl group, said alkyl and cycloalkyl group being substituted with one, two or three —OCORa group(s), or with one, two or three —OP(O)(OH)ORa group(s), one or more of the carbon atoms of said alkyl or cycloalkyl group being optionally replaced by a nitrogen atom, and
• Ra represents a (C1-C6)alkyl group, said alkyl group being optionally substituted by an amino group.