US 2026/0240838 A1 · USE OF NITRONE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF IN COMBINATION WITH SGLT-2 INHIBITORS

Abstract

The present invention provides a combination therapy of a nitrone compound or a pharmaceutically acceptable salt thereof with a SGLT-2 inhibitor. Research found that the nitrone compounds TBN and TN-2, when used in combination with a SGLT-2 inhibitor, can synergistically lower blood sugar and also reduce the 24-hour urinary microalbumin and urinary albumin creatinine ratio in db/db mice, demonstrating a protective effect on the kidneys. The inventor also unexpectedly discovered that the combination of the nitrone compound with the SGLT-2 inhibitor can reduce the risk of urinary and reproductive tract infections caused by SGLT-2 inhibitors.

Claims17

Dependent claims

A composition, characterized in that the composition comprises:

a therapeutically effective amount of a first active agent, which is a nitrone compound or a pharmaceutically acceptable salt thereof;
and
a therapeutically effective amount of a second active agent comprising a SGLT-2 inhibitor,
wherein, the nitrone compound has a structure of the following formula (I):
wherein:
R1 is hydrogen, methyl or
R2 and R3 are the same or different, each independently selected from hydrogen and C1-C6 alkyl;
R4 is sec-butyl, isobutyl, t-butyl, cyclopentyl or cyclohexyl, and R5 is sec-butyl, isobutyl, t-butyl, or cyclopentyl.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/831,144Filed 28 Feb 2023

Priority

CN 202210205372.22 Mar 2022

Published

20 Aug 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

A61K 31/4965
Having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines: non-condensed pyrazines
A61K 31/351
Having six-membered rings with one oxygen as the only ring hetero atom: not condensed with another ring
A61K 31/357
Having oxygen as the only ring hetero atom, e.g. fungichromin: having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
A61K 31/381
Having sulfur as a ring hetero atom: having five-membered rings

Use of nitrone compounds or pharmaceutically acceptable salts thereof in combination with sglt-2 inhibitors

Life of this patent

Use of nitrone compounds or pharmaceutically acceptable salts thereof in combination with sglt-2 inhibitors

Life of this patent

Abstract

Claims17