Compositions comprising inhibitors of microsomal triglyceride transfer protein and apo-b secretion

A composition comprising particles comprising a compound represented by Formula 1:

• or a pharmaceutically acceptable salt thereof;
• wherein
• R1 is optionally substituted alkyl, R4R5NC(O)CH2, cycloalkyl, heterocyclyl, or heterocyclylalkyl;
• X1 is a direct bond, O, S, —N(R6)—, C(O)NR6, or N(R6)C(O);
• X2 is O, —N(R6)—, or S;
• X3 is a direct bond, O, —N(R6)—, —CH2—, arylene, or S;
• R3 is H, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, heteroalkyl, aralkyl, alkylcarbonyl, alkoxycarbonyl, arylcarbonyl, aryloxycarbonyl, —OH, alkoxy, aryloxy, —SH, thioalkyl, thioaryl, or NR4R5;
• R4 and R5 are, independently for each occurrence, H, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, heteroalkyl, aralkyl, aminocarbonyl, alkylcarbonyl, alkoxycarbonyl, arylcarbonyl, or aryloxycarbonyl;
• R6 is, independently for each occurrence, H or alkyl;
• m is 0 or 1;
• and
• n is an integer from 0 to 3;
• provided that if m is 0, X3 is a direct bond or CH2;
• wherein each aryl or heteroaryl group is unsubstituted or substituted with one or more substituents selected from the group consisting of alkyl, hydroxy, alkoxy, alkylthio, cyano, halo, amino, and nitro;
• wherein each alkyl, cycloalkyl, heterocyclylalkyl, aralkyl, alkylcarbonyl, alkoxycarbonyl, arylcarbonyl, aryloxycarbonyl, alkoxy, aryloxy, thioalkyl, or thioaryl group is unsubstituted or substituted with one or more substituents selected from the group consisting of NH2, C1-C6 alkylamino, arylamino, diarylamino, heterocyclylamino, (C1-C6 alkyl)carbonylamino, C1-C6 alkoxy, C1-C6 alkylthio, oxo, ═S, halo, nitro, hydroxyl, cyano, aryl, heteroaryl, aryloxy, arylthio, carbocyclyl, carbocyclyloxy, carbocyclylthio, carbocyclylamino, heterocyclyl, heterocyclyloxy, and heterocyclylthio;
• wherein each heterocyclyl group is unsubstituted or substituted with one or more substituents selected from the group consisting of halo, alkyl, and aryl;
• and
• wherein at least 50% of the particles are characterized by a volume particle fraction less than 10 μm.