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US 2026/0240831 A1Published application
Cancer stratification and treatment
AssigneeDeutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
InventorsAna MARTIN-VILLALBA, Oguzhan KAYA, Leo FÖRSTER
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Abstract
The present invention relates to a modulator of wnt activity (wnt modulator) for use in treating a glioma in a subject, wherein cancer cells of said glioma were allocated to a multitude of lineage subpopulations, and to methods, databases, and uses related thereto.
Claims16
A method for treating a glioma in a subject, the method comprising:
- (I) determining whether the subject is susceptible to treatment with a wnt modulator by a method comprising allocating cancer cells of the glioma to a multitude of lineage subpopulations;
- and
- (II) treating the glioma in the subject based on the determining in step (I), the treating comprising:
- (a) administering a wnt modulator to the subject, and
- (b) thereby treating and/or preventing the glioma in the subject.
2 more elements
A method for evaluating glioma cancer cells comprising
- (a) determining at least three lineage biomarkers in a sample of said cancer cells;
- (b) comparing said at least three lineage biomarkers determined in step (a) to a lineage reference;
- and thereby
- (c1) evaluating said glioma cancer cells.
1 more element
A database comprising
- (I) at least three lineage biomarkers as a glioma cancer cell lineage reference;
- allocated to
- (II) at least one cancer cell subpopulation identifier.
(canceled)
Dependencies are inferred from the claim text.