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US 2026/0240813 A1Published application
Small molecule inhibitors of the bfrb:bfd interaction
AssigneesBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Kansas, The Board of Regents for Oklahoma State University
InventorsMario RIVERA, Huili YAO, Richard A. BUNCE, Baskar NAMMALWAR, Krishna Kumar GNANASEKARAN, Kate ESHELMAN, Achala N.D. Punchi HEWAGE, Scott LOVELL
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Abstract
The present technology provides compounds of Formula I and related methods for treating a bacterial infection as well as methods for inhibiting interaction of a bacterioferritin and a bacterioferritin-associated ferredoxin.
Claims21
1-26. (canceled)
A compound according to Formula I′
- or a pharmaceutically acceptable salt and/or a solvate thereof,
- wherein
- R1 is H, halo or OH;
- R2 is H or OH;
- R3 is H, C1-C6 alkoxy or OH;
- R4 is H or halo;
- R5 is H or halo;
- m is 0, 1 or 2;
- wherein when each of R1-R5 is H, then m=2;
- provided that when R1 is OH, then R2 is H, R3 is H or C1-C6 alkoxy, R4 is H or halo, R5 is H or halo, and m is 0 or 2;
- provided when R2 is OH, then each of R1, R3, R4, and R5 is H, and m is 1 or 2;
- provided when R3 is OH, then each R1 is independently H, halo or OH, R4 is independently H or halo, R2 is H or OH, R5 is H, and m is 0, 1 or 2;
- or
- wherein the compound is
11 more elements
Dependencies are inferred from the claim text.