Novel drug delivery systems and methods of making and using same
AssigneeThe Texas A&M University System
InventorsSrinath Palakurthi, Rishi Paliwal
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Abstract
A method of preparing a nanoparticle-active pharmaceutical ingredient adduct comprising contacting a nanoparticle with a solvent under conditions suitable for the formation of a solubilized nanoparticle; contacting the solvent-nanoparticle mixture with an active pharmaceutical ingredient under conditions suitable for forming a solubilized nanoparticle-active pharmaceutical ingredient adduct; contacting the solubilized nanoparticle-active pharmaceutical ingredient adduct with an adduct stabilizing agent to form a stabilized nanoparticle-active pharmaceutical ingredient adduct; and; recovering the stabilized nanoparticle-active pharmaceutical ingredient adduct.
Claims20
A method of preparing a nanoparticle-active pharmaceutical ingredient adduct, the method comprising:
- contacting a nanoparticle with a solvent under conditions suitable for the formation of a solvent-nanoparticle mixture;
- contacting the nanoparticle within the solvent-nanoparticle mixture with an active pharmaceutical ingredient under conditions suitable for forming a nanoparticle-active pharmaceutical ingredient adduct;
- contacting the nanoparticle-active pharmaceutical ingredient adduct with an adduct stabilizing agent to form a stabilized nanoparticle-active pharmaceutical ingredient adduct;
- and
- recovering the stabilized nanoparticle-active pharmaceutical ingredient adduct.
A method of preparing an immunosuppressive agent delivery system comprising:
- contacting a zein nanoparticle with an alcohol under conditions suitable for the formation of a solvent zein nanoparticle mixture;
- contacting the zein nanoparticle within the solvent zein nanoparticle mixture with an immunosuppressive agent under conditions suitable for forming a zein nanoparticle immunosuppressive agent adduct wherein the immunosuppressive agent comprises cyclosporine A;
- contacting the zein nanoparticle immunosuppressive agent adduct with an adduct stabilizing agent to form a stabilized zein nanoparticle immunosuppressive agent adduct, and
- recovering the stabilized zein nanoparticle immunosuppressive agent adduct.
Dependencies are inferred from the claim text.