Surface functionalized, host-guest polymer nano-assemblies and methods thereof

A nano-assembly comprising:

• a host crosslinked copolymer network having a functionalized surface with one or more functional groups;
• and
• a guest molecular cargo non-covalently encapsulated in the host crosslinked polymer network,
• wherein
• the host crosslinked copolymer network comprises a random copolymer having the structure:
• wherein
• each of Z1 and Z2 is independently
• wherein Z′ is selected from O, NH, NR (R=C1-C6 alkyl group or RF);
• each of R1 and R2 is independently selected from a hydrogen, C1-C12 alkyl group, or halogen;
• each of RL1 and RL2 is independently a single bond or a spacer group;
• RF is-H or a functional group;
• Rx is a crosslinking group capable of inter- or intra-molecular crosslinking;
• Rx′ is an inter- or intra-molecularly crosslinked group;
• and
• i=a·n, j=x·n, and k=b·n−x·n, wherein each of a and b is a positive number with a+b=1, each of n and x is independently an integer from about 0.1% to about 100% of b;
• and
• the host crosslinked copolymer network is addressable by a biological, physical or chemical intervention resulting in partial or complete decrosslinking of the host polymer network and release of the guest molecular cargo from the nano-assembly.