Pharmaceutical compositions with improved dissolution
AssigneeApplied Materials, Inc.
InventorsBalaji Ganapathy, Ankur Kadam, Jayesh Arun Patil, Vikas Gujar, Mousumi Das, Pravin K. Narwankar, Sushilkumar Dhanaji Patil
Life of this patent
Estimating the term…
Abstract
This disclosure pertains to a coated particle that has a drug-containing core and an inorganic coating layer and methods of preparing thereof. The coated particle has an improved solubility comparing to the uncoated drug-containing core. The drug-containing core comprises an active pharmaceutical ingredient (API) with a low solubility.
Claims26
A pharmaceutical composition, comprising:
- (a) a coated particle comprising an active pharmaceutical ingredient (API)-containing core and one or more discontinuous metal oxide or metalloid oxide coating layers, wherein the API-containing core has a median particle size, on a volume average basis, between 0.1 μm and 1000 μm, and
- (b) a pharmaceutically acceptable excipient.
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A method of preparing coated particles comprising active pharmaceutical ingredient (API)-containing core, a discontinuous zinc oxide coating layer and a discontinuous silicon oxide coating layer, the method comprising the sequential steps of:
- (a) loading particles comprising an API into the chamber of a reactor, wherein the particles have a median particle size, on a volume average basis between 0.1 μm and 1000 μm;
- (b1) applying vaporous or gaseous diethyl zinc to the particles in the reactor by pulsing the vaporous or gaseous diethyl zinc into the reactor;
- (b2) performing one or more pump-purge cycles of the reactor using an inert gas;
- (b3) applying vaporous or gaseous oxidant to the particles in the reactor by pulsing the oxidant into the reactor;
- (b4) performing one or more pump-purge cycles of the reactor using an inert gas;
- (c) repeating steps (b1)-(b4) at least once to create a discontinuous zinc oxide coating layer on the particles;
- (d1) applying vaporous or gaseous silicon tetrachloride to the particles in the reactor by pulsing the vaporous or gaseous silicon precursor into the reactor;
- (d2) performing one or more pump-purge cycles of the reactor using an inert gas;
- (d3) applying vaporous or gaseous water to the particles in the reactor by pulsing vaporous or gaseous water into the reactor;
- (d4) performing one or more pump-purge cycles of the reactor using an inert gas;
- and
- (e) repeating steps (d1)-(d4) at least once to create a discontinuous silicon oxide coating layer on the discontinuous zinc oxide coating layer.
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Dependencies are inferred from the claim text.