Dexamethasone prodrug compositions and uses thereof
AssigneeRipple Therapeutics Corporation
InventorsIan Charles PARRAG, Matthew Alexander John STATHAM, Kyle BATTISTON, Dimitra LOUKA, Hans Christian FISCHER, J. Paul SANTERRE, Wendy NAIMARK
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Abstract
The disclosure features pharmaceutical compositions formed from prodrug dimers for the extended delivery of a drug and for the treatment of a disease or condition.
Claims14
An implant comprising a steroid dimer of formula (A-VIII):
- or a pharmaceutically acceptable salt or solvate thereof
- wherein:
- D1 and D2 are each independently a steroid radical;
- and
- L is a linker covalently linking D1 to D2,
- the implant comprising at least 60% by weight (w/w) of steroid dimer of formula (A-VIII).
A method of treating an inflammatory disease or condition in a subject in need thereof, the method comprising administering to the subject an implant in an amount sufficient to treat the inflammatory disease or condition in the subject, wherein the implant comprises a steroid dimer of formula (A-VIII):
- or a pharmaceutically acceptable salt or solvate thereof wherein:
- D1 and D2 are each independently a steroid radical;
- and
- L is a linker covalently linking D1 to D2,
- the implant comprising at least 70% by weight (w/w) of steroid dimer of formula (A-VIII).
Dependencies are inferred from the claim text.