Solid oral dosage form comprising antibodies for sustained release in the lower gastrointestinal tract
AssigneeTillotts Pharma AG
InventorsRoberto Carlos BRAVO GONZALEZ, Ramon VOGLER
Life of this patent
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Abstract
The present invention relates to a solid oral dosage form for sustained release in the lower gastrointestinal tract, comprising antibodies or functional fragments thereof in a depot layer (2) covering an inert core unit (1), a sustained release layer (3) covering the depot layer, and a delayed release layer (4) covering the sustained release layer, preferably prepared by drug layering; an oral multiparticulate drug delivery system comprising a plurality of the solid oral dosage forms; and the use of the solid oral dosage form in the targeted local treatment in the lower gastrointestinal tract of a patient.
Claims42
A solid oral dosage form comprising
- i) an inert core unit (1);
- ii) a depot layer (2) covering the inert core unit (1) and comprising an antibody or a functional fragment thereof, as an active agent;
- and optionally a stabilizer, a buffer and/or a polymeric binder;
- iii) a sustained release layer (3), covering the depot layer (2) and comprising at least one cationic polymer;
- and optionally a plasticizer and/or an anti-tacking agent;
- and
- iv) a delayed release layer (4) covering the sustained release layer (3) and comprising at least one anionic polymer and optionally a plasticizer.
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Dependencies are inferred from the claim text.