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US 2026/0240759 A1Published application
Methods and apparatuses for delivering an agent through the vasa vasorum
AssigneeRenovoRx, Inc.
InventorsRamtin AGAH, Robert STRASSER
Life of this patent
Estimating the term…
Abstract
Described herein are methods and apparatuses (e.g., devices, systems, etc.) that may be used to deliver one or more agents (e.g., compounds, compositions, etc. including drugs, biologics, cells, etc.) to a target tissue in or adjacent to an adventitia through the vasa vasorum. These methods and apparatuses may be used to deliver relatively large agents to a target tissue in or adjacent to an adventitia specifically through the vasa vasorum.
Claims23
A method comprising:
- identifying a region of a vessel that is proximate to a target region and includes vasa vasorum;
- isolating the identified region of the vessel by occluding an upstream region of the vessel and a downstream region of the vessel;
- and
- delivering an agent through the vasa vasorum by applying the agent within the occluded identified region while maintaining a fluid pressure sufficient to force the agent across the arterial wall (through the vasa vasorum) within the isolated region.
1 more element
-18. (canceled)
(canceled)
A method for delivering an agent through vasa vasorum, the method comprising:
- identifying a region of a vessel that is proximate to a target region, wherein the region comprises vasa vasorum;
- isolating the identified region of the vessel by occluding both an upstream and a downstream region from the identified region;
- and
- delivering the agent through the vasa vasorum while the vasa vasorum is dilated by a vasodilator by applying the agent within the isolated region, wherein a fluid pressure within the isolated region is maintained.
1 more element
A method comprising:
- identifying a region of a vessel that is proximate to a target region and that has a density of vasa vasorum having an average diameter size of 10 μm or greater;
- isolating the identified region of the vessel by occluding an upstream region and a downstream region from the identified region;
- and
- delivering an agent within the isolated identified region under pressure to drive the agent into the vasa vasorum, wherein the pressure is maintained at 150 mmHg or less.
1 more element
-38. (canceled)
Dependencies are inferred from the claim text.