Molecular linkers
OwnerNancy Liyou, Christopher Elvininventors
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Abstract
The present disclosure relates to the crosslinking of endogenous proteins in a tissue using molecular linkers, and therapeutic compositions comprising the linkers. The present disclosure further relates to therapeutic methods and therapeutic compositions for the treatment of diseases and disorders.
Claims26
A method of crosslinking endogenous protein in a tissue, the method comprising:
- (i) contacting the tissue with a molecular linker, a photoactivatable metal ligand complex, and an electron acceptor, whereby the molecular linker contacts the endogenous protein in the tissue;
- and
- (ii) irradiating the tissue.
A method of treating a weakened corneal stroma in a subject, the method comprising:
- (i) administering a molecular linker, a photoactivatable metal ligand complex, and an electron acceptor to a cornea of the subject;
- and
- (ii) irradiating the cornea.
A method of treating or preventing at least one symptom of keratoconus in a subject, the method comprising:
- (i) administering a molecular linker, a photoactivatable metal ligand complex, and an electron acceptor to a cornea of the subject;
- and
- (ii) irradiating the cornea.
Use of a molecular linker in the manufacture of a medicament for the treatment or prevention of one or more symptoms of disease in a subject.
A composition for the treatment of keratoconus in a subject, the composition comprising a molecular linker, a photoactivatable metal ligand complex, and an electron acceptor.
A composition for intermolecular crosslinking between endogenous stromal collagen fibrils and other endogenous proteins in the cornea, wherein the composition comprises a molecular linker, a photoactivatable metal ligand complex, and an electron acceptor.
Dependencies are inferred from the claim text.