Systems and methods for compensating for agent elution

A glucose monitoring system, comprising:

• a glucose sensor including a working electrode configured for placement in a body of a user, the glucose sensor further including an agent elutable into body fluid;
• and
• a controller configured to:
• obtain, at a first time, a first electrochemical impedance spectroscopy (EIS) value of at least one parameter based on first EIS signals from the working electrode;
• obtain, at a second time after the first time, a second EIS value of the at least one parameter based on second EIS signals from the working electrode;
• determine, based on the first and second EIS values, a change in the at least one parameter;
• estimate, based on the change in the at least one parameter, a concentration of the agent;
• evaluate, using a model based at least in part on the concentration of the agent, a model effect indicative of an impact of the agent on a sensor glucose value;
• and
• generate or adjust the sensor glucose value based at least in part on the model effect.

A glucose monitoring system, comprising:

• a glucose sensor including a working electrode configured to generate sensor signals indicative of glucose and further configured to generate electrochemical impedance spectroscopy (EIS) signals, the glucose sensor including an agent elutable into body fluid;
• and
• a controller configured to:
• obtain a first impedance value from the EIS signals at a first time;
• obtain a second impedance value from the EIS signals at a second time after the first time;
• determine, based on the first impedance value and the second impedance value, a change indicative of elution of the agent;
• determine, based at least in part on the change, a compensation associated with the agent;
• and
• apply the compensation to the sensor signals to generate a compensated sensor glucose value.

A non-transitory processor readable medium storing instructions which, when executed by one or more processors, cause performance of a method comprising:

• obtaining, at a first time, a first electrochemical impedance spectroscopy (EIS) value of at least one parameter based on first EIS signals from a working electrode of a glucose sensor including an agent elutable into body fluid;
• obtaining, at a second time after the first time, a second EIS value of the at least one parameter based on second EIS signals from the working electrode;
• determining, based on the first and second EIS values, a change in the at least one parameter;
• estimating, based on the change in the at least one parameter, a concentration of the agent;
• evaluating, using a model based at least in part on the concentration of the agent, a model effect indicative of an impact of the agent on a sensor glucose value;
• and
• adjusting the sensor glucose value based at least in part on the model effect.