Spatially resolved diffuse reflectance for bilirubin measurement

Abstract

A 2D image sensor system for optical measurements of physiological parameters through a patient's skin using spatially resolved diffuse reflectance. The system includes a 2D image sensor adapted to be placed near/against the skin with at least three wavelength-dependent spectral channels and a field of view (FOV) with multiple spatial regions of interest (ROI). A source directs light onto the skin at a distance offset from the FOV. A detector receives light reflected from the skin and collects a 2D map of the entire reflectance spatial decay profile characteristic of the skin in different detector channels. A selector identifies multiple ROI that can be uniquely positioned in each spectral channel and/or partially overlapping in the 2D reflectance spatial decay map as the elements of a multivariate regression model to approximate a physiological parameter. The increased dimensionality of the system outputs improves measurement accuracy and reduces bias in confounding optical factors.

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