Nitric oxide-releasing compositions and applications thereof

Abstract

Described herein are compositions comprising a nitric oxide-releasing material comprising a (i) a polysiloxane network and (ii) a plurality of nitric oxide-donating moieties covalently bonded to the polysiloxane network; and (b) a nanonemulsion comprising a surfactant and a hydrophobic solvent. Also described herein are articles composed of the compositions described herein and methods for using the same. The compositions described herein provide highly sustained, long-term nitric oxide release that have numerous biological activities such as, for example, preventing localized platelet activation, fibrinogen adhesion, and biofilm formation for a prolonged period of time.

Dependencies are inferred from the claim text.