Iterative image reconstruction with upscaling

A non-transitory computer-readable medium having stored thereon instructions that, when executed by a processor, cause the processor to perform the following:

• obtain projection image data associated with a target structure of a patient;
• perform iterative image reconstruction for a first number of iterations to generate first volume image data based on the projection image data, wherein the first volume image data is associated with a first resolution level;
• upscale the first volume image data associated with the first resolution level to generate second volume image data associated with a second resolution level, wherein the second resolution level is higher than the first resolution level;
• and
• perform iterative image reconstruction for a second number of iterations to generate output volume image data associated with the second resolution level based on the second volume image data.

An imaging system, comprising:

• an imaging source and a detector to acquire projection image data associated with a target structure of a patient;
• and
• a computer system configured to:
• perform iterative image reconstruction for a first number of iterations to generate first volume image data based on the projection image data, wherein the first volume image data is associated with a first resolution level;
• upscale the first volume image data associated with the first resolution level to generate second volume image data associated with a second resolution level, wherein the second resolution level is higher than the first resolution level;
• and
• perform iterative image reconstruction for a second number of iterations to generate output volume image data associated with the second resolution level based on the second volume image data.