Multiplexed biosensing system for detecting pomc derivatives
AssigneeZomedica Biotechnologies LLC
InventorsIan Harmon, Vicci Korman
Life of this patent
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Abstract
An analyte detection system and method is described that provides for separate and accurate quantification of the levels of POMC derivatives CLIP and intact ACTH present in a sample. The system may include at least two sensors. In one example of the system of the present invention, primary antibodies are immobilized at the sensor surfaces to capture the analyte (intact ACTH or CLIP), and secondary antibodies are provided to bind to the captured analyte to permit detection of the analyte. The quantification of both intact ACTH and CLIP may provide information about whether a subject (e.g., an animal being evaluated by a veterinarian) is suffering from an ailment. The system may include a cartridge.
Claims20
An analyte detection system, comprising:
- a first surface, configured to receive an amount of a sample taken from an animal;
- a second surface, configured to receive an amount of the sample;
- wherein the first surface includes a first analyte capture material configured to capture intact ACTH from the sample;
- wherein the second surface includes a second analyte capture material configured to capture CLIP from the sample;
- and
- wherein measurement results of the levels of intact ACTH and CLIP found in the sample are jointly considered to indicate when there is the presence of disease in the animal.
An analyte detection system, comprising:
- a processor;
- a first sensor, configured to receive an amount of a sample;
- a second sensor, configured to receive an amount of the sample;
- wherein the first sensor is configured to detect intact ACTH in the sample;
- wherein the second sensor is configured to detect CLIP in the sample;
- and
- wherein the processor is configured to determine total ACTH for the sample based on detected intact ACTH in the sample and detected CLIP in the sample.
A biological testing method, comprising:
- providing a first sensor in a cartridge adapted for analyte detection, said first sensor configured to receive an amount of a sample taken from a mammal;
- providing a second sensor in the cartridge, said second sensor configured to receive an amount of the sample taken from the mammal;
- configuring the first sensor to detect intact ACTH in the sample;
- configuring the second sensor to detect CLIP in the sample.
Dependencies are inferred from the claim text.