Bladder cancer detection proteins and methods of use thereof
AssigneeNovelna Inc.
InventorAshkan Afshin
Life of this patent
Estimating the term…
Abstract
Methods of evaluating a subject for bladder cancer or detecting bladder cancer in a subject, the methods comprising determining in a biological sample from the subject a concentration of one or more proteins selected from Table 1. The methods may further comprise applying a classifier to the concentration of the one or more proteins that identifies whether the concentration of the one or more proteins is indicative of the subject having bladder cancer. In addition, methods of treatment comprising administering a treatment to the subject when the subject is evaluated or detected to have bladder cancer.
Claims65
A method of evaluating a subject for bladder cancer, the method comprising:
- determining in a biological sample from the subject a concentration of one or more proteins selected from Table 1;
- thereby evaluating the subject for cancer.
A method of treating bladder cancer in a subject, the method comprising:
- (a) acquiring results from an evaluation of the subject that determined the subject has bladder cancer;
- (b) administering a treatment to the subject,
- wherein the evaluation comprises:
- (i) determining in a biological sample from the subject a concentration of one or more proteins selected from Table 1;
- and
- (ii) applying a classifier to the concentration of the one or more proteins to identify whether the subject has bladder cancer.
The method of any one of claims 4-8, wherein the results in (a) are acquired from a third party.
A method of detecting bladder cancer in a subject, the method comprising:
- determining in a biological sample from the subject a concentration of one or more proteins selected from Table 1;
- and
- applying a classifier to the concentration of the one or more proteins that identifies whether the concentration of the one or more proteins is indicative that bladder cancer is detected.
A method of treating bladder cancer in a subject, the method comprising
- determining in a biological sample from the subject a concentration of one or more proteins selected from Table 1;
- applying a classifier to the concentration of the one or more proteins that identifies whether the concentration of the one or more proteins is indicative that bladder cancer is detected;
- and
- administering a treatment to the subject when bladder cancer is detected.
A method of treating bladder cancer in a subject in whom bladder cancer was detected, the method comprising administering a treatment for bladder cancer to the subject, wherein bladder cancer was detected in the subject by a method comprising:
- determining in a biological sample from the subject a concentration of one or more proteins selected from Table 1;
- and
- applying a classifier to the concentration of the one or more proteins that identifies whether the concentration of the one or more proteins is indicative that bladder cancer is detected.
A method of evaluating a treatment for bladder cancer in a subject, the method comprising:
- (a) administering a treatment for bladder cancer, and
- (b) determining in a biological sample from the subject a concentration of one or more proteins selected from Table 1;
- thereby evaluating the treatment.
A method of evaluating the efficacy of a treatment for bladder cancer in a subject, the method comprising
- (a) administering a treatment for bladder cancer to the subject, and
- (b) determining in a biological sample from the subject a concentration of one or more proteins selected from Table 1;
- thereby evaluating the efficacy of the treatment.
A method of treating bladder cancer in a subject, the method comprising
- (a) administering a treatment for bladder cancer to the subject, and
- (b) determining in a biological sample from the subject a concentration of one or more proteins to evaluate the efficacy of the treatment, wherein the one or more proteins are selected from Table 1.
A method of adjusting a treatment for bladder cancer in a subject, the method comprising
- (a) administering a treatment for bladder cancer to the subject,
- (b) determining in a biological sample from the subject a concentration of one or more proteins, wherein the one or more proteins are selected Table 1, and
- (c) administering an adjusted treatment to the subject when it is determined that the adjusted treatment is necessary.
A method of treating bladder cancer in a subject, the method comprising
- (a) administering a treatment for bladder cancer to the subject, and
- (b) determining in a biological sample from the subject a concentration of one or more proteins to evaluate whether the treatment requires adjustment, wherein the one or more proteins are selected from Table 1.
A method of monitoring for bladder cancer recurrence in a subject, the method comprising
- (a) administering a treatment for bladder cancer to the subject, and
- (b) determining in a biological sample from the subject a concentration of one or more proteins to evaluate whether the bladder cancer is recurring, wherein the one or more proteins are selected from Table 1.
A method of treating bladder cancer in a subject, the method comprising
- (a) administering a treatment for bladder cancer to the subject, and
- (b) determining in a biological sample from the subject a concentration of one or more proteins to evaluate whether cancer is recurring, wherein the one or more proteins are selected from Table 1.
A method of measuring amounts of proteins in a subject, the method comprising determining individual amounts of one or more proteins selected from Table 1.
Dependencies are inferred from the claim text.