Method and reagents for the detection of an autoantibody
AssigneesEUROIMMUN Medizinische Labordiagnostika AG, Hospices Civils De Lyon, Universite Claude Bernard Lyon 1, Centre National De La Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale
InventorsRamona MISKE, Madeleine SCHARF, Yvonne Müller, Christiane RADZIMSKI, Christian PROBST, Lars KOMOROWSKI, Jérôme HONNORAT, Le Duy DO, Anne-Laurie PINTO
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Abstract
A method detects, in a sample, an antibody binding specifically to NECAB1. An antibody binds specifically to NECAB1. A carrier such as a diagnostically useful carrier with a solid phase with an immobilized polypeptide has an antigen or at least one epitope thereof or a variant of the antigen or epitope thereof, wherein the antigen is NECAB1. The antibody can be used for diagnosing an autoimmune disease or a cancer.
Claims16
A method, comprising:
- detecting in a sample a mammalian autoantibody binding specifically to NECAB1.
A kit, comprising:
- a polypeptide comprising NECAB1 or an epitope thereof or a variant of NECAB1 or the epitope thereof, and
- a secondary antibody specifically binding to human immunoglobulins.
A method, comprising:
- using a polypeptide comprising NECAB1 or at least one epitope thereof or a variant of NECAB1 or the epitope thereof or an autoantibody binding specifically to NECAB1 or a recombinant antibody binding specifically to NECAB1 for the manufacture of an analytical kit or medical device, for diagnosing or aiding in the diagnosis of associated with the presence of a mammalian autoantibody binding specifically to NECAB1.
An ex vivo method, comprising:
- removing a mammalian autoantibody binding specifically to NECAB1 from blood.
Dependencies are inferred from the claim text.