P21-activated kinase 4 inhibition and e-cadherin expression inducer and screening method therefor

Abstract

The present specification pertains to a method for screening a p21-activated kinase (PAK4) inhibition and E-cadherin expression inducer using the novel mechanism of PAK4's regulation of E-cadherin expression and to a PAK4 inhibitor and E-Cadherin expression inducer, according to the method, useful for the prevention, treatment, or metastasis inhibition of cancer, particularly pancreatic cancer. Through the novel mechanism by which PAK4 regulates E-Cadherin expression, it is possible to develop targeted therapies for cancer or metastatic cancer effectively. Particularly provided can be first-in-class innovative new drugs in the field of pancreatic cancer or metastatic cancers derived from pancreatic cancer, where there is currently an unmet need due to the lack of effective treatments.

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