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US 2026/0235579 A1Published application
Methods of generating organoids for high throughput screening of drugs
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsYaakov NAHMIAS, Avner EHRLICH, Muneef AYYASH
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Abstract
Methods of generating organoids on multi-well plates are provided by depositing a polymeric solution comprising cells under conditions which result in a homogenous population of organoids, which can be used for high throughput analysis for drug screening and for determining treatment regimens of a drug.
Claims20
A method of generating a single organoid on a surface, the method comprising:
- forming at an end of a liquid channel a drop of a polymeric solution comprising cells;
- while said drop is connected to said end, operating a robotic arm to establish a contact between a surface of said drop and a surface which is characterized by a water contact angle of at least 70 degrees;
- releasing said drop from said end;
- and
- incubating said drop under conditions that promote formation of the single organoid.
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Dependencies are inferred from the claim text.