Sample-testing system for measuring properties of red blood cells
AssigneeOrange Biomed Ltd., Co.
InventorsUng Hyeon Ko, Eun Young Park, Seung Jin Kang
Life of this patent
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Abstract
The present disclosure relates to systems, devices and methods for measuring analyte levels. A glycated hemoglobin level measuring system includes a sample-testing cartridge having a microchannel that passively transfers and compresses cells. The system can perform one or more calibration or normalization routines on sensor data to generate calibrated or normalized data. The calibrated or normalized data can be used to determine one or more analyte levels.
Claims27
1-12. (canceled)
A method for analyzing cells in a fluid sample of a subject, the method comprising:
- transferring, via capillary action, a plurality of cells through a microchannel sized to compress the cells;
- measuring, using one or more sensor circuits positioned along the microchannel, a plurality of travel parameters corresponding to the plurality of cells traveling through the microchannel;
- comparing a distribution characteristic of the measured plurality of travel parameters to a plurality of known travel parameter distribution characteristics, wherein each of the known travel parameter distribution characteristics corresponds to a different analyte level;
- and
- determining, based at least in part on the comparison, an analyte level of the cells.
A method for analyzing cells in a patient fluid sample, the method comprising:
- receiving, from one or more sensor circuits positioned along a microchannel, a plurality of signals corresponding to a plurality of travel parameters of cells traveling through the microchannel, wherein the microchannel is sized to compress the cells and transfer the cells therethrough via capillary action;
- comparing a distribution characteristic of the plurality of travel parameters to a plurality of known travel parameter distribution characteristics, wherein each of the known travel parameter distribution characteristics corresponds to a different analyte level;
- and
- determining, based at least in part on the comparison, an analyte level of the cells.
A method for filtering data associated with cells in a patient fluid sample, the method comprising:
- receiving, from one or more sensor circuits positioned along a microchannel, a plurality of signals corresponding to a plurality of travel parameters of cells traveling through the microchannel, wherein the microchannel is sized to compress the cells and transfer the cells therethrough via capillary action;
- removing one or more outlier signals from the plurality of the signals to generate a filtered signal subset, wherein the one or more outlier signals correspond to travel parameters falling outside of a predetermined range;
- and
- determining an analyte level of the cells based on the filtered signal subset.
Dependencies are inferred from the claim text.