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AssigneesTestmate Health SA, CSEM Centre Suisse d'Electronique et de Microtechnique SA
InventorsHüseyin Baris Atakan, Noa Schmid, Roger Limacher, Georg Orawez, Stephan Bitterli, Elie Graham, Gaëtan Cherbuin
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The present disclosure relates to a system and method for a nucleic acid amplification device for testing a bodily fluid sample for illness. In some embodiments, the device comprises a housing having an inlet port and an incubation and detection section configured to enable the amplification and the detection of nucleic acids. At least one first microfluidic conduit connects the inlet port with at least one incubation chamber. At least one nucleic acid amplification composition including a primer configured to amplify nucleic acids indicative of an illness, is located along the first microfluidic conduit and/or in the incubation chamber. In some embodiments, the device further comprises a heating arrangement comprising a heating element adjacent the at least one incubation chamber.
A nucleic acid amplification device for testing a bodily fluid sample for illness, the device comprising a housing comprising:
The amplification device according to any of the previous claims,
The amplification device according to any of the previous claims, wherein the incubation and detection section comprises at least one test strip, wherein the test strip has been functionalized to change in color upon presence of a threshold amount of DNA and/or RNA.
The amplification device according to any of the previous claims, wherein the incubation and detection section comprises a leuco dye, preferably a leuco dye configured to turn to a blue color to enable detection, and/or wherein the incubation and detection section comprises a rhodamine B—Cu dye which changes color in the presence of pyrophosphate.
A single-use nucleic acid amplification device for testing a bodily fluid sample for illness, the device comprising a housing comprising:
The amplification device according to any of the previous claims,
The amplification device according to any of the previous claims, wherein the amplification device further comprises
The amplification device according to any of the previous claims, wherein an electrical circuit between a power supply of the heating arrangement and the heating element is open in the absence of sample within the amplification device, and wherein the electrical circuit is closed upon the presence of sample within the amplification device, preferably wherein the sample acts as an electrical conductor to close the electrical connection between the power supply and the heating element.
The amplification device according to any of the previous claims, wherein the device comprises a plurality of incubation chambers, wherein the heating arrangement is configured to heat each of the incubation chambers to a respective target temperature, wherein the target temperature differs between the incubation chambers, preferably wherein one or more incubation chambers that are to be heated to a higher target temperature are arranged between incubation chambers that are to be heated to a lower target temperature.
The amplification device according to any of the previous claims,
Dependencies are inferred from the claim text.