Modified capsid proteins for enhanced intra-articular delivery of adenovirus-associated virus (aav) vectors

An adenovirus-associated virus (AAV) capsid protein comprising a capsid protein amino acid sequence from AAV6, wherein the variable region 1 (VR1) loop comprising amino acid residues 258 to 271 of AAV6 capsid protein is modified by deletion and/or substitution of one or more amino acid residues, wherein the capsid protein comprising the modification provides to an AAV vector comprising the capsid protein increased transduction efficiency and increased ability to evade neutralizing antibodies when administered intra-articularly, relative to an AAV vector comprising an unmodified AAV6 capsid protein.