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US 2026/0234664 A1Published application
Pharmaceutical compositions viral particles and methods of using the same
AssigneeInterius Biotherapeutics, Inc.
InventorsMuneeswara Babu Medi, Timothy D. Culp, Richard W. Peluso
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Abstract
Provided for herein are pharmaceutical compositions comprising a virus, such as lentiviruses, including pseudotyped lentiviruses and uses thereof. Also provided for herein are methods of using the pharmaceutical compositions.
Claims58
A pharmaceutical composition comprising:
- (i) a lentiviral vector;
- (ii) a pharmaceutically acceptable buffer at a concentration of about 5 mM to about 100 mM;
- (iii) a pharmaceutically acceptable salt at a concentration of about 100 mM to about 800 mM;
- (iv) a sugar in an amount of about 1% (w/v) to about 5% (w/v);
- and
- (v) a protein excipient in an amount of about 0.1% (w/v) to about 3% (w/v),
- wherein the pharmaceutical composition has a pH of about 6.0 to about 8.0.
4 more elements
A pharmaceutical composition comprising:
- (i) a VSV-G pseudotyped lentivirus
- (ii) about 10 mM to about 30 mM of a L-Histidine buffer;
- (iii) about 100 mM to about 400 mM of sodium chloride;
- (iv) about 1% (w/v) to about 5% (w/v) of sucrose;
- and
- (v) about 0.1% (w/v) to about 2% (w/v) of a non-recombinant human serum albumin,
- wherein the pharmaceutical composition has a pH of about 5.5 to about 8.0.
4 more elements
A pharmaceutical composition comprising:
- (i) a VSV-G pseudotyped lentivirus comprising a VSV-G polypeptide comprising a mutation that corresponds to a mutation at position 182, 214, and/or 352 of SEQ ID NO:
- 2;
- (ii) L-Histidine buffer at a concentration of about 10 mM to about 30 mM;
- (iii) sodium chloride at a concentration of about 100 mM to about 400 mM;
- (iv) sucrose in amount of about 1% (w/v) to about 5% (w/v);
- and
- (v) non-recombinant human serum albumin in an amount of about 0.1% (w/v) to about 2% (w/v),
- wherein the pharmaceutical composition has a pH of about 6.5 to about 7.5.
5 more elements
Dependencies are inferred from the claim text.