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US 2026/0234655 A1Published application
Nuclear Targeted DNA Delivery and Compositions for Use in Practicing the Same
AssigneeSeawolf Therapeutics, Inc.
InventorsRob BURKE, Brian LAMB, Niv SCOTT, Marco PROIETTO, Sataree KHUANSUWAN, Samuel Wyman BEPPLER, Oliver John DANSEREAU, Elizabeth ALCAMO
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Abstract
Methods of nuclear targeted DNA delivery are provided. Aspects of the methods include contacting a cell with: (a) a nuclear targeted deoxyribonucleic acid (NTDNA) that includes a DNA nuclear targeting sequence (DTS) and a cargo nucleic acid heterologous to the DTS. Also provided are compositions for use in practicing methods of the invention.
Claims24
A method of delivering a cargo nucleic acid sequence into the nucleus of a cell, the method comprising:
- contacting the cell with a nuclear targeted deoxyribonucleic acid (NTDNA) comprising
- a) a DNA nuclear targeting sequence (DTS) comprising a targeting factor binding sequence (TFBS) for a nuclear targeting factor (NTF), and
- b) a cargo nucleic acid heterologous to the DTS;
- to deliver the cargo nucleic acid sequence to the nucleus of the cell.
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Dependencies are inferred from the claim text.