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US 2026/0234642 A1Published application
Microbial Respiration of Chloroxyanions as a Source of Oxygen for Bioprocessing
AssigneeThe Regents of the University of California
InventorJohn D. Coates
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Abstract
Aerobic microbial processes comprise culturing microbes comprising a (per)chlorate respiration pathway in a bioreactor in a bioprocess employing microbial respiration of chloroxyanions as a source of oxygen for the bioprocess, in the absence of external addition of molecular oxygen.
Claims7
A method of aerobic microbial processing comprising:
- culturing microbes comprising a (per)chlorate respiration pathway in a bioreactor in a bioprocess employing microbial respiration of chloroxyanions as a source of oxygen for the bioprocess, in the absence of external addition of molecular oxygen,
- wherein the microbes are genetically engineered to comprise an operative microbial (per)chlorate respiration pathway encoding:
- (i) a perchlorate reductase which effects reduction of (per)chlorate to chlorite (ClO2−), or a protein belonging to the DMSO reductase superfamily of molybdopterin oxidoreductases which effects reduction of (per)chlorate to chlorite;
- (ii) a chlorite dismutase which effects dismutation of the chlorite into chloride and molecular oxygen (O2);
- and
- (iii) a cytochrome oxidase which effects reduction of the molecular oxygen;
- wherein the pathway enables the engineered microbe to grow in the bioreactor with (per)chlorate as its sole electron acceptor in the absence of oxygen.
4 more elements
Dependencies are inferred from the claim text.