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US 2026/0234593 A1Published application
Method of producing collagenase
AssigneeEndo Operations Limited
InventorsChristine A. Sheaffer, Michael Berbaum, John Hanna, Jason Dziadosz, Daniel Shanafelt
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Abstract
The present invention relates to the fields of collagenase production and collagenase products, and particularly to improving the reproducibility, purity, and stability of collagenase I and collagenase II compositions, where the compositions are pure to at least 95% by area as measured by reverse phase high pressure liquid chromatography (RP-HPLC) and essentially free of neutral protease.
Claims16
A process intermediate comprising:
- a bacterial collagenase enzyme;
- a bacterial metalloprotease enzyme, wherein the metalloprotease enzyme is not a collagenase enzyme;
- a zinc content of less than about 80 ppm;
- and
- a nickel content of less than about 2.0 ppm.
2 more elements
Dependencies are inferred from the claim text.