Composition including virus like particles (vlps), a kit, and method for antitumoral therapy

Abstract

A composition for use in antitumoral therapy, where the composition combines two virus like particles (VLPs) capable of promoting an abscopal effect. The composition can include: a VLP-derived from a viral capsid decorated with VSV-g envelope glycoprotein and loaded with Thymidine Kinase (HSV-TK) from viral herpes; a VLP-derived from a viral capsid decorated with CD40L; and/or a combination thereof. A kit is disclosed for antitumoral therapy, where the kit includes: a VLP-derived from a viral capsid decorated with VSV-g envelope glycoprotein and loaded with HSV-TK from viral herpes; a VLP-derived from viral capsid decorated with CD40L; and (c) an antiviral drug, where the VLPs are derived from a lentivirus capsid. A method is disclosed for antitumoral therapy, where the method involves administration of two VLPs capable of promoting an abscopal effect, and an antiviral drug.

Dependencies are inferred from the claim text.