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US 2026/0234568 A1Published application
Tumor storage and cell culture compositions
AssigneeIovance Biotherapeutics, Inc.
InventorsKenneth ONIMUS, Anand VEERAPATHRAN, Arvind NATARAJAN, Ulrich ERNST
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Abstract
Provided herein are tumor storage compositions, cell culture media, and tumor wash buffers, useful for the production of TIL therapeutics. The reagents allow for the production of high quality TIL therapeutics while reducing microbial bioburden and providing sterility assurance in the TIL manufacturing process.
Claims18
1-298. (canceled)
A composition for hypothermic storage of a tumor sample, the composition comprising:
- i. a serum-free, animal component-free cryopreservation medium;
- and
- ii. an antibiotic component comprising either:
- 1) a combination of antibiotics selected from:
- i. gentamicin and vancomycin,
- ii. gentamicin and clindamycin, and
- iii. gentamicin and amphotericin B;
- or
- iv. an antibiotic that is vancomycin
6 more elements
A tumor sample composition comprising:
- i. a tumor sample comprising a plurality of tumor cells and a plurality of tumor infiltrating lymphocytes (TILs);
- and
- ii. a hypothermic storage medium comprising:
- i. a serum-free, animal component-free cryopreservation medium;
- and
- ii. an antibiotic component comprising either:
- I) a combination of antibiotics selected from:
- 1. gentamicin and vancomycin,
- 2. gentamicin and clindamycin, and
- 3. gentamicin and amphotericin B;
- or
- an antibiotic that is vancomycin, wherein optionally the cryopreservation medium comprises 10% DMSO.
9 more elements
Dependencies are inferred from the claim text.