Fluorescent cone reporter ips cells, retinal organoids and uses thereof
AssigneeThe Saban Research Institute; Children's Hospital Los Angeles
InventorsDavid Cobrinik, Jinlun Bai
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Abstract
Fluorescent reporter pluripotent stem cell (PSC) lines are powerful tools to investigate cell type-specific development and disease phenotypes. When combined with live imaging, they enable direct and repeated observation of cell behaviors within a developing tissue. Provided herein is a novel human cone photoreceptor reporter line and retinal organoids that can track cone development.
Claims22
A pluripotent stem cell line with a genetic modification that allows expression of either a) a protein and/or or b) a tamoxifen inducible Cre recombinase under control of an endogenous GNAT2 promoter.
A pluripotent stem cell derived, in vitro generated, retinal cell line, retinal tissue or retinal organoid (ROs) comprising either a) a protein and/or or b) a tamoxifen inducible Cre recombinase under control of an endogenous GNAT2 promoter.
A retinal organoid comprising a population of human pluripotent derived photoreceptor (PR) cells comprising either a) a protein and/or or b) a tamoxifen induced Cre recombinase under control of an endogenous GNAT2 promoter.
Dependencies are inferred from the claim text.