Microorganisms and methods for reducing by-products

Abstract

The present disclosure provides nonrnaturally occurring microbial organisms having eliminate, substantially eliminate, or reduced production of unwanted by-products (e.g, 3HB, acetate, and others) and/or to enhance or increase carbon flux through 3 HB—CoA, and/or 3HBAId, and/or the CoA thioesters or acyl-CoAs of unwanted by-products, which can increase production of acetyl-CoA derived compounds (e.g, 1,3-BDO, MMA, and (3R)-hydroxybutyl (3R)-hydroxybutyrate, or any other acetyl-CoA derived compounds), and products made from any of these compounds. Also provided are one or more exogenous nucleic acids encoding enzymes that can eliminate, substantially eliminate, or reduce production of unwanted by-products (e.g, 3HB, acetate, and others) and/or that can enhance or increase carbon flux through 3HB—CoA, 3HBAId, and/or the CoA thioesters/acyl-CoAs of unwanted by-products.

Dependencies are inferred from the claim text.