Compositions of hydroxypropyl-beta-cyclodextrin and methods of purifying the same
AssigneeBeren Therapeutics P.B.C.
InventorsSteven Pfeiffer, Dustin McMinn, Gabor Benkovics
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Abstract
The present disclosure relates to compositions comprising mixtures of hydroxypropyl-β-cyclodextrin, wherein the compositions may be isomerically purified. The disclosure also relates to methods of isomerically purifying a mixture of hydroxypropyl-β-cyclodextrins.
Claims9
A composition comprising a mixture of isomerically-purified hydroxypropyl-β-cyclodextrin molecules substituted at one or more of the 2-O position, the 3-O position, and the 6-O position on each of the cyclodextrin subunits with one or more hydroxypropyl groups, wherein the mixture of β-cyclodextrin molecules is substituted at the 2-O— position at a rate of about 35% to about 55%, the mixture of β-cyclodextrin molecules is substituted at the 3-O— position at a rate of about 26% to about 32%, and the mixture of β-cyclodextrin molecules is substituted at the 6-O— position at a rate of about 0% to about 20%, and wherein the mixture has an average degree of substitution of 7 to 9.
Dependencies are inferred from the claim text.