Senescent cell-associated antigen-binding domains, antibodies and chimeric antigen receptors comprising the same, and uses thereof
AssigneeStarkAge Therapeutics
InventorsMüge Ogrunc, Thierry Mathieu
Life of this patent
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Abstract
Disclosed are senescent cell-associated antigen-binding domain and related antibodies and related chimeric antigen receptors. In addition, disclosed are DPP4-binding domains and related antibodies and related chimeric antigen receptors. Also disclosed are methods for treating, preventing or alleviating senescence-related diseases or disorders. Methods for depleting and/or killing senescent cells are also disclosed.
Claims11
-20. (canceled)
An antibody drug conjugate (ADC) comprising an antibody or an antigen-binding fragment thereof, comprising a DPP4-binding domain, comprising a combination of three heavy chain variable region (HCVR)'s complementary-determining regions (CDRs) and three light chain variable region (LCVR)'s CDRs, said combination being as defined in any row of the table below, wherein the CDRs are defined by their SEQ ID NO:
- VH-
- VH-
- VH-
- VL-
- VL-
- VL-
- Clone’s name
- CDR1
- CDR2
- CDR3
- CDR1
- CDR2
- CDR3
- 5826-13-R3A-A10
- 107
- 119
- 137
- 146
- 157
- 170
- 5826-13-R3A-B1
- 108
- 120
- 138
- 147
- 158
- 171
- 5826-13-R3A-B3
- 108
- 121
- 138
- 147
- 159
- 171
- 5826-13-R3A-D5
- 109
- 122
- 139
- 148
- 160
- 172
- 5826-13-R3A-D6
- 108
- 123
- 138
- 149
- 159
- 171
- 5826-13-R4A-E2
- 108
- 124
- 138
- 147
- 159
- 171
- 5826-13-R4A-E6
- 110
- 125
- 140
- 146
- 161
- 170
- 5826-13-R4A-E9
- 108
- 126
- 141
- 149
- 159
- 171
- 5826-13-R4A-F10
- 108
- 126
- 138
- 150
- 159
- 171
- 5826-13-R4A-G11
- 108
- 126
- 138
- 150
- 159
- 171
- 5826-13-R4A-G12
- 111
- 127
- 138
- 151
- 159
- 171
- 5826-13-R4A-H1
- 110
- 128
- 140
- 146
- 162
- 170
- 5826-13-R4A-H2
- 108
- 126
- 141
- 149
- 159
- 171
- 5826-13-R4A-H3
- 108
- 126
- 138
- 149
- 159
- 173
- 5826-13-R4A-H4
- 112
- 125
- 140
- 146
- 162
- 170
- 5826-13-R4A-H5
- 108
- 127
- 138
- 147
- 159
- 171
- 5826-13-R4A-H6
- 108
- 127
- 142
- 147
- 159
- 171
- 5826-13-R4A-H9
- 108
- 123
- 138
- 149
- 159
- 171
- 5826-13-R4A-H10
- 110
- 125
- 140
- 146
- 162
- 170
- 5826-13-R4A-H11
- 110
- 128
- 140
- 146
- 162
- 170
- 5826-13-R4A-H12
- 110
- 125
- 140
- 146
- 163
- 170
Dependencies are inferred from the claim text.