Cd163-binding conjugates
AssigneesVib Vzw, Vrije Universiteit Brussel
InventorsJo Van Ginderachter, Geert Raes, Cécile Vincke, Nick Devoogdt, Timo De Groof, Yoline Lauwers
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Abstract
The invention relates to polypeptides, in particular polypeptides comprising an immunoglobulin domain, binding to human and murine CD163 protein and to applications of such polypeptides such as for use as diagnostic agent, for example as an immunotracer. The invention further relates to conjugates, in particular conjugates of polypeptides comprising an immunoglobulin domain binding to human and murine CD163 protein and a further moiety, such as a therapeutic moiety, and to applications of such conjugates.
Claims21
A single domain antibody (sdAb) comprising a CDR1 region, a CDR2 region, and a CDR3 region, wherein the CDR1, CDR2 and CDR3 regions are selected from those CDR1, CDR2 and CDR3 regions as present in an immunoglobulin variable domain (IVD) defined by SEQ ID NO:1 and as determined by the Kabat, Chothia, Martin, or IMTG method.
2-15. (canceled)
Dependencies are inferred from the claim text.