Bispecific polypeptide molecule
AssigneeEnara Bio Limited
InventorsMagdalena VON ESSEN, Duncan HOWIE, Peter MASON, Emily LAM, Terri CORNFORTH
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Abstract
The present invention relates to bispecific polypeptide molecules capable of simultaneously binding to a disease associated antigen and a cell surface antigen expressed on the surface of an immune effector cell such as a T-cell resulting in the activation of the immune effector cell.
Claims28
A bispecific polypeptide molecule capable of simultaneously binding a first and second antigen, wherein the bispecific polypeptide molecule comprises a first polypeptide chain and a second polypeptide chain, wherein:
- (A) the first polypeptide chain comprises:
- (i) a first antigen-binding domain, (ii) a first hinge domain subunit, (iii) a first Fc domain subunit;
- and
- (B) the second polypeptide chain comprises:
- (i) a second antigen-binding domain, ii) a second hinge domain subunit, (iii) a second Fc domain subunit;
- wherein the first and second hinge domain subunits are capable of forming a stable association as a hinge domain and the first and second Fc domain subunits are capable of forming a stable association as an Fc domain or Fc domain portion, such that the two polypeptide chains are connected by covalent and/or non-covalent bonds between the hinge domain subunits and Fc-domain subunits, preferably wherein the first and second antigens are expressed on two distinct cells.
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Dependencies are inferred from the claim text.