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US 2026/0234264 A1Published application
Anti-vista antibodies and fragments
AssigneeJanssen Pharmaceutica NV
InventorsLinda Snyder, Gordon Powers
Life of this patent
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Abstract
The present invention relates to novel antibodies and fragments that bind to a V-domain Ig Suppressor of T cell Activation (VISTA), and methods of making and using same. Methods of use include methods of treatment of cancer, including leukemias, lymphomas, solid tumors and melanomas.
Claims25
1-103. (canceled)
An anti-human VISTA antibody or antigen binding fragment thereof which
- (i) comprises a variable heavy chain polypeptide wherein the CDR1, CDR2 and CDR3 polypeptides respectively comprise SEQ ID NO:
- 1, 2 and 3, and comprises a variable light chain polypeptide wherein the CDR1, CDR2 and CDR3 polypeptides respectively comprise SEQ ID NO:
- 4, 5 and 6;
- (ii) comprises a variable heavy chain polypeptide wherein the CDR1, CDR2 and CDR3 polypeptides respectively comprise SEQ ID NO:
- 7, 8 and 9, and comprises a variable light chain polypeptide wherein the CDR1, CDR2 and CDR3 polypeptides respectively comprise SEQ ID NO:
- 10, 11 and 12;
- (iii) comprises a variable heavy chain polypeptide wherein the CDR1, CDR2 and CDR3 polypeptides respectively comprise SEQ ID NO:
- 13, 14 and 15, and comprises a variable light chain polypeptide wherein the CDR1, CDR2 and CDR3 polypeptides respectively comprise SEQ ID NO:
- 16, 17 and 18;
- (iv) comprises a variable heavy chain polypeptide wherein the CDR1, CDR2 and CDR3 polypeptides respectively comprise SEQ ID NO:
- 19, 20 and 21, and comprises a variable light chain polypeptide wherein the CDR1, CDR2 and CDR3 polypeptides respectively comprise SEQ ID NO:
- 22, 23 and 24;
- or
- (v) comprises a variable heavy chain polypeptide wherein the CDR1, CDR2 and CDR3 polypeptides respectively comprise SEQ ID NO:
- 31, 32 and 33, and comprises a variable light chain polypeptide wherein the CDR1, CDR2 and CDR3 polypeptides respectively comprise SEQ ID NO:
- 34, 35 and 36.
13 more elements
Dependencies are inferred from the claim text.