Inhibitors of il11ra based signalling

An IL11RA inhibitor comprising

• a first IL11RA binding polypeptide comprising an amino acid residue sequence selected from
• i)
• A1S2A3T4F5P6X7Q8C9X10X11Q12L13M14D15L16G17F18
• P19X20Y21A22V23X24A25A26L27X28Y29T30N31G32N33C34
• E35X36A37A38S39L40L41F42X43R44 according to SEQ
• ID NO:
• 2
• wherein, independently of each other,
• X7 is R, V or I;
• X10 is A, L, D, E, T, V, I or Y;
• X11 is W, A, R or F;
• X20 is Q, A, R, V, L or F;
• X24 is I, A, H, V, L, F or Y;
• X28 is R, H, V, L, I, F or Y;
• X36 is R, A, H, T, Q, V, L, I, F or Y;
• X43 is A or H;
• and
• ii) an amino acid residue sequence having at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98% or at least 99% identity to the sequence defined in i);
• and comprising
• a second IL11RA binding polypeptide comprising a binding motif (BM), said (BM) consisting of an amino acid residue sequence selected from
• iii)
• XaWXbAWXcEIXdXeLPNLNXfWQXgAAFIXhASLXi
• according to SEQ ID NO:
• 3
• wherein, independently of each other,
• Xa is A or L;
• Xb is Q or A;
• Xc is D or A;
• Xd is D, A, T, V, I or L;
• Xe is H, A, R, S, T, Q, I, L, F or Y;
• Xf is P or A;
• Xg is K, A, T or I;
• Xh is L or A;
• Xi is L or A;
• and
• iv) an amino acid residue sequence which has at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98% or at least 99% identity to the sequence defined in iii).