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US 2026/0234159 A1Published application
Small molecule treatment of fatty liver disease and hcc
AssigneeScandiEdge Therapeutics AB
InventorsAdil MARDINOGLU, Mathias UHLÉN, Jan BORÉN, Jihad SEBHAOUI, Sajda ASHRAF, Shazia IQBAL
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Abstract
There is provided a compound of formula (I) or a pharmaceutically acceptable salt thereof.
Claims21
A compound of formula (I)
- or a pharmaceutically acceptable salt thereof, wherein:
- both are single bonds or double bonds;
- X is selected from —(CH2)2— and —NR3— when is a single bond;
- X is —CH— when is a double bond;
- R1 is independently selected from a carbonyl and a sulphonyl;
- R2 is selected from the group consisting of
- R3 is selected from the group consisting of —H,
- R4 is
- M is N or CH;
- R5 is —H, halide,
- R6 is —H, -Me or phenyl;
- and
- R7 is C1-C3 alkyl or an optionally substituted aryl;
- provided that it is not a compound according to any one of formulae (II)-(V).
11 more elements
(canceled)
A method of treating fatty liver disease or hepatocellular carcinoma (HCC) comprising administering to a subject in need thereof a compound according to formulae (V) or (VII)
Dependencies are inferred from the claim text.