Non-covalent dimer cation of purine/pyrimidine and amino acid, salt thereof, preparation method therefor, and use thereof
AssigneeSuzhou Protonation Chain Biotechnology Co., Ltd
InventorsZizhen Zhao, Zhigang Wang
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Abstract
Provided is a non-covalent dimer cation of the present application, comprising or consisting of a cation of formula [+Q1-H···Q2], a tautomer thereof, or a stereoisomer thereof. Provided is a salt of the present application, including the cation of the present application and a first anion. Provided is use of the cation of the present application or the salt of the present application, for example, use in the preparation of a medicament for promoting cell repair, cell proliferation, or wound repair.
Claims19
A non-covalent dimer cation, comprising or consisting of a cation of formula [+Q1-H···Q2], a tautomer thereof, or a stereoisomer thereof,
- wherein a bond “···” in formula [+Q1-H···Q2] is a non-covalent bond;
- one of Q1 and Q2 is a first moiety, and the other is a second moiety;
- the first moiety is selected from a group consisting of formula (R), formula (Y), and dihydro derivatives thereof, and the second moiety is formula (A),
- wherein R is selected from a group consisting of no group, —H, —CH3, ═CH2, —NH2, ═NH, —OH, ═O, —F, β-D-ribofuranosyl, and 2-deoxy-β-D-ribofuranosyl;
- and
- —L2 is H, and —L1 is selected from a group consisting of hydrogen, methyl, hydroxymethyl, mercaptomethyl, selenomethyl, aminomethyl, carboxymethyl, carbamoylmethyl, methylthiomethyl, guanidinomethyl, ethyl, 1-hydroxyethyl, 2-hydroxyethyl, 1-mercaptoethyl, 2-mercaptoethyl, 1-aminoethyl, 2-aminoethyl, 1-carboxyethyl, 2-carboxyethyl, 1-carbamoylethyl, 2-carbamoylethyl, 1-methylthioethyl, 2-methylthioethyl, 1-guanidinoethyl, 2-guanidinoethyl, n-propyl, isopropyl, 1-hydroxypropyl, 2-hydroxypropyl, 3-hydroxypropyl, 1-mercaptopropyl, 2-mercaptopropyl, 3-mercaptopropyl, 1-aminopropyl, 2-aminopropyl, 3-aminopropyl, 1-carboxypropyl, 2-carboxypropyl, 3-carboxypropyl, 1-carbamoylpropyl, 2-carbamoylpropyl, 3-carbamoylpropyl, 1-methylthiopropyl, 2-methylthiopropyl, 3-methylthiopropyl, 1-guanidinopropyl, 2-guanidinopropyl, 3-guanidinopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, 4-aminobutyl, 1-hydroxybutyl, 2-hydroxybutyl, 3-hydroxybutyl, 4-hydroxybutyl, 2 1-mercaptobutyl, 2-mercaptobutyl, 3-mercaptobutyl, 4-mercaptobutyl, 1-aminobutyl, 2-aminobutyl, 3-aminobutyl, 4-aminobutyl, 1-carboxybutyl, 2-carboxybutyl, 3-carboxybutyl, 4-carboxybutyl, 1-carbamoylbutyl, 2-carbamoylbutyl, 3-carbamoylbutyl, 4-carbamoylbutyl, 1-methylthiobutyl, 2-methylthiobutyl, 3-methylthiobutyl, 4-methylthiobutyl, 1-guanidinobutyl, 2-guanidinobutyl, 3-guanidinobutyl, 4-guanidinobutyl, benzyl, 2-hydroxybenzyl, 3-hydroxybenzyl, 4-hydroxybenzyl, (pyrrol-4-yl)methyl, (indol-3-yl)methyl, and (3-methyl-3,4-dihydropyrrole-2-carbonyl)aminobutyl;
- or —L1 and —L2 together form a group selected from a group consisting of propane-1,3-diyl, butane-1,4-diyl, and pentane-1,5-diyl.
9-10. (canceled)
Dependencies are inferred from the claim text.