Compounds for treating opioid misuse

A compound of Formula (II):

• or pharmaceutically acceptable salt thereof, wherein:
• RA1 is hydrogen, substituted or unsubstituted C1-12 alkyl, substituted or unsubstituted 3- to 13-memberedcycloalkyl, substituted or unsubstituted 3- to 13-membered heterocyclyl, substituted or unsubstituted 6- to 12-membered aryl ring, substituted or unsubstituted 5- to 14-membered heteroaryl ring, or a nitrogen protecting group;
• RA2 is hydrogen, substituted or unsubstituted C1-12 alkyl, substituted or unsubstituted 3- to 13-memberedcycloalkyl, substituted or unsubstituted 3- to 13-membered heterocyclyl, substituted or unsubstituted 6- to 12-membered aryl ring, substituted or unsubstituted 5- to 14-membered heteroaryl ring, or a nitrogen protecting group;
• or RA1 and RA2 are joined with the intervening nitrogen atom to form a 3- to 13-membered heterocyclyl or 3- to 13-membered heteroaryl, wherein the heterocyclyl or heteroaryl is substituted or unsubstituted;
• RA3 is hydrogen, substituted or unsubstituted C1-12 alkyl, or an oxygen protecting group;
• RA4 is hydrogen, substituted or unsubstituted C1-12 alkyl, or an oxygen protecting group;
• and
• RA5 is hydrogen, substituted or unsubstituted C1-12 alkyl, or an oxygen protecting group.

A compound of Formula (III):

• or a pharmaceutically acceptable salt thereof, wherein:
• RB1 is hydrogen, halo, —OH, —O(C1-6 alkyl), or C1-6 haloalkyl;
• RB2 is hydrogen, substituted or unsubstituted C1-12 alkyl, or an oxygen protecting group;
• RB3 is hydrogen, substituted or unsubstituted C1-12 alkyl, or an oxygen protecting group;
• RB4 is hydrogen, —OH, —OMe, —OEt, or absent, as valency permits;
• and
• each instance of is either a single or double bond.

A compound of Formula (IV):

• or a pharmaceutically acceptable salt thereof, wherein:
• RB1 is hydrogen, halo, —OH, —O(C1-6 alkyl), or C1-6 haloalkyl;
• RB3 is hydrogen, substituted or unsubstituted C1-12 alkyl, or an oxygen protecting group;
• RB4 is hydrogen, —OH, —OMe, —OEt, or absent, as valency permits;
• and
• each instance of is either a single or double bond.

A compound of Formula (V):

• or a pharmaceutically acceptable salt thereof, wherein:
• RB1 is hydrogen, halo, —OH, —O(C1-6 alkyl), or C1-6 haloalkyl;
• RB3 is hydrogen, substituted or unsubstituted C1-12 alkyl, or an oxygen protecting group;
• RB4 is hydrogen, —OH, —OMe, —OEt, or absent, as valency permits;
• and
• each instance of is either a single or double bond.

A compound of Formula (VI):

• or pharmaceutically acceptable salt thereof, wherein:
• RC1 is hydrogen, —OH, or —OMe;
• RC2 is hydrogen, unsubstituted C1-6 alkyl, or C1-6 alkyl substituted with one or more instances of —OH, —OMe, fluoro, indolyl;
• each instance of RC3 is hydrogen or both instances of R3C are taken together to form:
• each instance of RC4 is hydrogen or both instances of RC4 are taken together to form:
• ═O;
• and
• n is 0, 1, or 2.

A compound of Formula (VII):

• or pharmaceutically acceptable salt thereof, wherein:
• RC1 is hydrogen, —OH, or —OMe;
• X1 is CH or N;
• and
• X2 is NH, CH2, or CH—(CH2)—OMe.

A compound of Formula (VIII):

• or pharmaceutically acceptable salt thereof, wherein:
• m is 1, 2, or 3;
• and
• each instance of RD1 is hydrogen or both instances of RD1 are taken together to form:

A compound of Formula (IX):

• or pharmaceutically acceptable salt thereof, wherein:
• RE1 is hydrogen, —OH, or —OMe;
• each instance of RE2 is hydrogen or both instances of RE2 are taken together to form:
• ═O;
• and
• each instance of RE3 is hydrogen or both instances of RE3 are taken together to form: