EP2 Antagonist Compounds

A compound having the formula

• wherein
• R1 and R2 are independently selected from Ra, —ORd, —C1-4 haloalkyl, or together R1 and R2 form an oxo, C3-6 membered cycloalkyl or 3-6 membered cycloheteroalkyl;
• R3 is —CH(Rb)2, —C(Rb)3, —S(O)2Rd, —S(O)2ORd, —S(O)2NRcRc, —S(O)(NRa)Rd, —S(O)2N(Ra)S(O)2Ra, —S(O)2N(Ra)S(O)2NRcRc, —C(O)Rd, —C(O)N(Ra)C(O)Rd, —C(O)ORd, —C(O)NRcRc;
• Ring A and Ring B independently are selected from phenyl and cycloalkyl;
• X is selected from hydrogen and Rb;
• each RA is independently selected from halogen;
• —CN, —C1-4 alkyl, and —C1-4 haloalkyl;
• each RB is independently selected from the group consisting of halogen, —CN, —C1-4 alkyl, —C1-4 haloalkyl, —C1-4 aminoalkyl, —C1-4 hydroxyalkyl, —C1-4 methoxyalkyl, —(C1-4 alkyl)O(C1-4 alkyl), —C(O)(C1-4 alkyl), —C(O)OH, —C(O)O(C1-4 alkyl), —C(O)NRcRc, —NRcRc, —NH(C3-6 cycloalkyl), —NH(C3-6 heterocycloalkyl) and substituted or unsubstituted C3-6 cycloalkyl;
• each Ra is independently selected from the group consisting of hydrogen, (C1-6) alkyl and (C3-8) cycloalkyl;
• each Rb is independently selected from the group consisting of —ORd, —OCF2H, —OCF3, —NRcRc, halogen, —CF3, —CN, —S(O)2Rd, —S(O)2ORd, —S(O)2NRcRc, —C(O)Rd, —C(O)ORd, —C(O)NRcRc,
• each Rc is independently Ra, or, alternatively, two Rc are taken together with the nitrogen atom to which they are bonded to form a 5 to 8-membered cycloheteroalkyl or 5-membered heteroaryl, which may optionally include one or more of the same or different additional heteroatoms and which may optionally be substituted with one or more of the same or different —C(O)Ra and Ra groups;
• each Rd is independently selected from hydrogen and (C1-6) alkyl optionally substituted with 1, 2 or 3 groups selected from halogen and —O(C1-4 alkyl);
• and
• n is, for each occurrence, independently, 0 to 3;
• provided that the compound is not a compound disclosed in PCT/US22/34903.