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AssigneeMirai Medical Limited
InventorsDeclan SODEN, Sean KINSELLA, Jason McNAMARA, Colin FORDE, Cian KERRIGAN
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Irreversible electroporation of mammalian cells is achieved by an electroporation apparatus comprising a controller, a drive circuit controlled by the controller to generate drive pulses, and at least two electrodes linked with the drive circuit for delivering the pulses. The controller causes the drive circuit to provide pulses in: (a) a reversible electroporation group of pulses sufficient to create/open cell pores and/or disrupt cell membranes of tissue near the electrodes, (b) an electrophoretic group of one or more pulses with lower voltages, and (c) repetition of (a) and (b) in N cycles, N having a value of 0 to 100. This achieves IRE with lower voltages and less patient discomfort.
An electroporation apparatus comprising a controller, a drive circuit controlled by the controller to generate drive pulses, and at least two electrodes linked with the drive circuit for delivering the pulses, wherein the controller is configured to cause the drive circuit to provide pulses in:
The apparatus as claimed in claim 12, wherein the group (b) of pulses include pulses having parameters to induce a stress on the cell membrane, enlarging the cell pores from the group (a) and to facilitate electrophoresis within the tissue, accelerating the loss of ions from the electroporated cells, reducing the capacity for recovery and triggering non-thermal cell death;
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A method of treatment of tissue in a mammal, the treatment being carried out with use of a probe having at least two electrodes and a drive circuit controlled by a controller to generate drive pulses, wherein the controller causes the drive circuit to provide pulses in:
Dependencies are inferred from the claim text.