Heomstatic sealant powder for sealing leaks in tissues
AssigneesGuangzhou Bioseal Biotech Co., Ltd., Ethicon, Inc.
InventorsSHUANG CHEN, YAPING WANG, XUEQIN DENG, YUFU LI, TINGWAN XIE, HAI LI, XUEMEI ZHANG
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Abstract
Disclosed herein are powdered compositions comprised of fibrinogen, thrombin, glycerol-water solution, and optionally oxidized cellulose (OC), wherein the glycerol is present at a concentration ranging from about 0.7% to about 6%, by weight; and wherein the OC is present at a concentration below about 9%, by weight, or is absent. Methods of making the compositions, and uses of the compositions in methods for treating a bleeding tissue, and for sealing leaks in tissues are further disclosed.
Claims30
A powdered composition comprising fibrinogen, thrombin, glycerol-water solution and optionally oxidized cellulose (OC), wherein:
- (i) the glycerol is present at a concentration ranging from about 0.7% to about 6.5%, by weight;
- and wherein:
- (ii) the OC is present at a concentration below about 9%, by weight, or is absent.
A method of making a powdered hemostatic composition, comprising the steps of:
- (a) mixing a solid fibrinogen, thrombin, and optionally ORC fibers, forming a mixture;
- (b) inserting the mixture in high shear mixing reactor;
- (c) adding a solution of glycerol and water to said mixture in the reactor;
- (d) drying and sieving the composition obtained in step (c), and thus forming the powdered hemostatic composition.
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Dependencies are inferred from the claim text.