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US 2026/0232850 A1Published application
Compositions and methods for targeting tumor-associated macrophages
AssigneeResolute Science
InventorFaith Hemenway BARNETT
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Abstract
The present disclosure relates to compositions that target tumor associated macrophages. The compositions disclosed here preferably comprise a glucan backbone, a tumor-associated macrophage targeting moiety, a targeting moiety linker, a payload and optionally a payload linker. The present disclosure also provides methods of making such compositions. The present disclosure also provides methods of treatment using such compositions.
Claims32
A method of treating a solid tumor comprising administering to a subject in need thereof a composition, wherein the composition comprises:
- i) a tumor-associated macrophage-targeting moiety;
- ii) a glucan backbone, wherein the glucan backbone comprises a plurality of backbone monomers;
- iii) an active component comprising a dodecane tetraacetic acid (DOTA) substrate, wherein the active component is coupled to the glucan backbone, and wherein the DOTA substrate is chelated to a radioisotope;
- and
- iv) a targeting linker that links the tumor-associated macrophage-targeting moiety to the glucan backbone, wherein the targeting linker comprises a carbamate group and a chain moiety, wherein the carbamate group is connected to the backbone monomer and the chain moiety connects the carbamate group and the tumor-associated macrophage-targeting moiety.
2 more elements
A composition comprising:
- i) a tumor-associated macrophage-targeting moiety;
- ii) a glucan backbone, wherein the glucan backbone comprises a plurality of backbone monomers;
- iii) an active component comprising a dodecane tetraacetic acid (DOTA) substrate, wherein the active component is coupled to the glucan backbone, and wherein the DOTA substrate is chelated to a radioisotope selected from the group consisting of:
- 212Bi, 131I, 111In, 90Y, 186Re, 211At, 125I, 188Re, 153Sm, 213Bi, and 32P;
- and
- iv) a targeting linker that links the tumor-associated macrophage-targeting moiety to the glucan backbone, wherein the targeting linker comprises a carbamate group and a chain moiety, wherein the carbamate group is connected to the backbone monomer and the chain moiety connects the carbamate group and the tumor-associated macrophage-targeting moiety.
3 more elements
Dependencies are inferred from the claim text.