Cd59 for inhibiting inflammasome activation
AssigneeTrustees of Tufts College
InventorsRajendra Kumar-Singh, Binit Kumar, Siobhan M. Cashman
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Abstract
Methods and kits are provided for inhibiting inflammasome activation in cells of a subject or an inflammation-affected eye in a subject by administering to the subject a composition including a nucleotide sequence encoding a membrane independent CD59 protein operably linked to a promoter for expression and secretion of the membrane independent CD59 protein in the cells or the inflammation-affected eye, the composition inhibiting inflammasome activation.
Claims19
-52. (canceled)
A method for treating uveitis in a subject afflicted with autoimmune uveitis, the method comprising:
- administering to the subject a composition comprising a nucleic acid encoding a membrane independent CD59 protein operably linked to a promoter for expression and secretion of the membrane independent CD59 protein in cells of inflammation-affected eye in the subject, wherein the composition inhibits inflammasome activation, and wherein the subject has displayed positive results for expression or activity of at least one inflammasome activity marker in the inflammation-affected eye of the subject.
A method for treating uveitis in an inflammation-affected subject afflicted with autoimmune uveitis, the method comprising measuring an inflammasome activity marker in the subject, and if the inflammasome activity marker is positive administering to the subject a composition comprising:
- i. a nucleic acid encoding a membrane independent CD59 protein operably linked to a promoter for expression and secretion of the membrane independent CD59 protein in cells of the inflammation-affected subject;
- or
- ii. a soluble CD59 protein;
- wherein the composition inhibits inflammasome activation.
A method for treating uveitis in an inflammation-affected subject afflicted with autoimmune uveitis, by administering to the subject a composition comprising:
- a. a nucleic acid encoding a membrane independent CD59 protein operably linked to a promoter for expression and secretion of the membrane independent CD59 protein in cells of the inflammation-affected subject;
- or
- b. a soluble CD59 protein;
- wherein the composition inhibits inflammasome activation, and wherein the subject has displayed positive results for expression or activity of at least one inflammasome activity marker.
A method for treating uveitis in an autoimmune uveitis afflicted subject, by administering to the subject a composition comprising:
- a. a nucleic acid encoding a membrane independent CD59 protein operably linked to a promoter for expression and secretion of the membrane independent CD59 protein in cells of the inflammation-affected subject;
- or
- b. a soluble CD59 protein
- wherein the composition inhibits inflammasome activation.
A method for treating uveitis in an inflammation-affected subject afflicted with autoimmune uveitis, the method comprising administering to the subject a composition comprising a nucleic acid encoding a membrane independent CD59 protein operably linked to a promoter for expression and secretion of the membrane independent CD59 protein in cells of the inflammation-affected subject, wherein the composition inhibits inflammasome activation, wherein the subject has displayed positive results for expression or activity of at least one inflammasome activity marker.
Dependencies are inferred from the claim text.