Affibody micelle drug conjugate
AssigneeKowa Company, Ltd.
InventorsKenichi SUZUKI, Hideo YOSHIDA, Nobuhiro FUJIMAKI
Life of this patent
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Abstract
A copolymer includes a copolymer X and a target-specific molecule bonded to the copolymer X. The copolymer X includes structural units of formulas (A), (B) and (C), where R1, R2, and R3 are the same or different and are hydrogen or C1-3 alkyl, R4 is C1-3 alkyl, R5 is hydrogen, C1-18 alkyl, a 3- to 8-membered cycloalkyl optionally having a substituent, an adamantyl, a C6-18 aryl optionally substituted, or a 5- to 10-membered heteroaryl group optionally substituted, X1, X2, and X3 are the same or different and are oxygen, sulfur, or N—R7, R6 is hydrogen, leaving group, or linker, R7 is hydrogen or C1-3 alkyl group, m is 1 to 100, and n is 0 to 3.
Claims22
A copolymer, comprising:
- a copolymer X;
- and
- a target-specific molecule bonded to a copolymer X,
- wherein the copolymer X includes structural units of formula (A), formula (B), and formula (C),
- where R1, R2, and R3 are the same or different and are a hydrogen atom or a C1-3 alkyl group, R4 is a C1-3 alkyl group, R5 is a hydrogen atom, a C1-18 alkyl group, a 3- to 8-membered cycloalkyl group optionally having a substituent, an adamantyl group, a C6-18 aryl group optionally having a substituent, or a 5- to 10-membered heteroaryl group optionally having a substituent, X1, X2, and X3 are the same or different and are an oxygen atom, a sulfur atom, or N—R7, R6 is a hydrogen atom, a leaving group, or a linker, R7 is a hydrogen atom or a C1-3 alkyl group, m is an integer of 1 to 100, and n is an integer of 0 to 3.
3-16. (canceled)
(canceled)
Dependencies are inferred from the claim text.