Multiple formats of molecular complexes
AssigneeFrontAim Biomedicines, Inc.
InventorDonglin Liu
Life of this patent
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Abstract
The present invention relates to multispecific molecule complexes. Particularly, this disclosure relates to multispecific protein complexes, such as multispecific antibodies, platform for making different formats of such complexes, and related uses. Multi-specific protein complexes, in which two or more target-specific moieties are engineered into a single molecule or complex, have expanded rapidly in recent years and offer an attractive solution for broad range of clinical and diagnostics applications. For example, bispecific antibodies and fusion proteins have been developed for binding to more than one antigen or to more than one epitope on the same antigen.
Claims25
A protein complex, comprising
- a first moiety comprising two immunoglobulin light chains and two immunoglobulin heavy chains, wherein either the two light chains or the two heavy chains are linked to two dimerization/docking domain (DDD) moieties respectively, and
- a second moiety comprising (i) an anchoring domain (AD) moiety and (ii) an agent linked to the AD moiety, wherein the two DDD moieties form a dimer that binds to the AD moiety.
A fusion protein comprising
- (i) a dimerization/docking domain (DDD) moiety and
- (ii) an immunoglobulin light chain fused to the DDD moiety, or an immunoglobulin heavy chain fused to the DDD moiety.
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An antibody or antigen-binding fragment thereof that specifically binds to human Trop2, comprising:
- (i) a light chain or a light chain variable region that comprises LCDR1, LCDR2 and LCDR3 comprising the respective sequences of SEQ ID NOs:
- 27-29, and/or
- (ii) a heavy chain or a heavy chain variable region that comprises HCDR1, HCDR2, and HCDR3 comprising the respective sequences of SEQ ID NOs:
- 30-32.
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Dependencies are inferred from the claim text.