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US 2026/0232822 A1Published application
Protein-antiviral compound conjugates
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsAlina BAUM, Thomas Nittoli
Life of this patent
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Abstract
Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with influenza, including VX-787 and derivatives thereof, baloxavir and derivatives thereof, and baloxavir marboxil and derivatives thereof, and protein (e.g., antibody) drug conjugates thereof.
Claims22
1-58. (canceled)
The linker payload compound selected from:
- or a pharmaceutically acceptable salt thereof, wherein
- SP1 and SP2, when present, are spacer groups;
- RG is a moiety reactive with an antibody or an antigen binding fragment thereof;
- each AA is an amino acid;
- and
- n is an integer from one to ten.
3 more elements
(canceled)
65-72. (canceled)
The linker-payload compound selected from the group consisting of:
Dependencies are inferred from the claim text.