Pharmaceutical compositions comprising protein complexes
AssigneeOnchilles Pharma, Inc.
InventorsCourt R. TURNER, Lev BECKER, Chang CUI
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Abstract
Provided are pharmaceutical compositions comprising alpha-2-macroglobulin (A2M) and a serine protease protein such as porcine pancreatic elastase (PPE), which are bound together in a protein complex that retains the CD95 protease cleavage and cancer-cell killing activities of the serine protease, but sterically hinders binding of the serine protease to fibrinogen and serine protease inhibitors; and related methods of use and manufacture for treating diseases such as cancers.
Claims35
A pharmaceutical composition, comprising a protein complex of:
- (a) alpha-2-macroglobulin (A2M) proteins;
- and
- (b) serine protease proteins,
- wherein (a) and (b) are present in the composition at a molar ratio [(a):(b)] of about 1:3 to about 1:1.
A method of manufacturing a pharmaceutical composition comprising a protein complex, by combining:
- (a) alpha-2-macroglobulin (A2M) proteins;
- and
- (b) serine protease proteins,
- into a composition at a molar ratio [(a):(b)] of about 1:3 to about 1:1, thereby manufacturing the pharmaceutical composition comprising the protein complex.
Dependencies are inferred from the claim text.